Why is Jet Relief™ So Effective?

Jet Relief™ is a breakthrough formula that effectively combines the most powerful and extensively researched ingredients, giving you a dual-action solution for combating jet lag. Every single ingredient in Jet Relief™ was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help reduce mental and physical stress during the journey, as well as, quickly balance sleep/wake cycles (circadian rhythms) upon arrival, and get results more effectively than any other jet lag remedy available.

Jet Relief™ contains 11 tested ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close in terms of quality and purity of ingredients.

Recommended use for adults is to take 2 capsules 30 minutes before take off and 2 capsules on arrival. Capsules should be taken a minimum of 4 hours apart. Consequently, take 1 capsule daily until the effects of jet lag have completely disappeared.

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Jet Relief™ - Comprehensive Blend of Ingredients:

Magnesium supplementation is commonly used to combat stress and restlessness by promoting a sense of muscular and physical calm. One of the main symptoms of magnesium deficiency is chronic insomnia, so getting an adequate balance of magnesium is important to fighting fatigue. It is needed for a variety of basic bodily functions, including regulating your heart and positive benefits for blood pressure and nervous system. Furthermore, if the body does not have adequate levels of magnesium, the body cannot produce serotonin and melatonin, both essential in balancing mood and regulating sleep patterns. It is an essential mineral that works together with Calcium. A balanced ratio of these two minerals create important chemical activity to support a tired and stressed body.

*References:
Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2012;17(12):1161-1169.
Ayuk J., Gittoes N.J. (Mar 2014). "Contemporary view of the clinical relevance of magnesium homeostasis". Annals of Clinical Biochemistry 51 (2): 179–88
Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and fluoride. Washington DC: The National Academies Press. ISBN 0-309-06403-1

Calcium is an essential element that acts as a signal for many cellular processes within the body and is an important component of a healthy diet. In order for the body to absorb calcium, it needs magnesium – and vice versa. Put simply, the role of calcium is to contract the muscles while, on the other hand, magnesium's job is to relax them. Deficiencies in Calcium can cause restlessness and wakefulness. Furthermore, during your flight, the body can become dehydrated. So, as well as drinking water, you need to replenish electrolytes such as calcium and magnesium. Magnesium and Calcium are essential for many enzyme reactions involved in energy metabolism.




*References:
Reid IR, Bristow SM, Bolland MJ (2015). "Calcium supplements: benefits and risks". J. Intern. Med. (Review).
Dietary Supplement Fact Sheet: Calcium". Office of Dietary Supplements, NIH.
Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and fluoride. Washington DC: The National Academies Press. ISBN 0-309-06403-1.

Vitamin B vitamins are essential for growth, development and many other bodily functions. These essential nutrients help convert our food into 'fuel', ensuring that we stay energized through the day, and of course, sleep well at night. If deficiencies occur, then a range of symptoms such as depression, fatigue and weakened memory may occur. Vitamin B6, B2 and B12 are included for optimal support to combat jet lag as well as elevate mood, increase attention and boost immunity.




*References:
Ebben, M.; A Lequerica; A Spielman (2002). "Effects of Pyridoxine on Dreaming: a Preliminary Study". Perceptual and Motor Skills 94 (1): 135–40. doi:10.2466/pms.2002.94.1.135. PMID 11883552. Retrieved 2012-05-23. The effect of pyridoxine (Vitamin B-6) on dreaming was investigated in a placebo, double-blind study to examine various claims that Vitamin B-6 increases dream vividness or the ability to recall dreams.
Kashanian, M.; Mazinani, R.; Jalalmanesh, S. (2007). "Pyridoxine (vitamin B6) therapy for premenstrual syndrome". International Journal of Gynecology & Obstetrics 96 (1): 43–4.
Vogiatzoglou A, Refsum H, Johnston C et al. (2008). "Vitamin B12 status and rate of brain volume loss in community-dwelling elderly". Neurology 71 (11): 826–32.

L-ornithine is an amino acid which has the potential to relieve stress and improve sleep quality related to fatigue, ideal for overcoming jet lag. A variety of studies suggest that L-ornithine can promote a more efficient use of energy. Kidneys convert ornithine into arginine, which is a precursor for nitric oxide (NO2 production). NO2 boosts oxygen levels and supply to muscles and tissue promoting physical strength and endurance. Furthermore, it helps the body recover from physical exhaustion and promotes positive sleep patterns.




*References:
Mika Miyake, et. al., “Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers," Nutrition Journal 2014, 13:53
Sugino, T; Shirai, T; Kajimoto, Y; Kajimoto, O (2008). "L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism". Nutrition research 28 (11): 738–43.
Demura, S; Yamada, T; Yamaji, S; Komatsu, M; Morishita, K (2010). "The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise". European journal of clinical nutrition 64 (10): 1166–71.

L-theanine is an amino acid, that can both sharpen mental focus and calm anxiety at the same time. It is able to cross the blood-brain barrier as well as induce changes on alpha waves in the brain, promoting a relaxed and alert state at the same time. It has been studied for its potential to reduce mental and physical stress, as well as calming, relaxing and tranquilizing properties also.




*References:
K. Kobayashi et al., “Effects of L‑Theanine on the Release of Alpha-Brain Waves in Human Volunteers," Journal of the Agricultural Chemical Society of Japan 72, no. 2 (1998): 153–157.
L-theanine. Review of Natural Products. Facts &Comparisons Online. April 2010.
Kimura, Kenta; Ozeki, Makoto; Juneja, Lekh Raj; Ohira, Hideki (2007). "L-Theanine reduces psychological and physiological stress responses". Biological Psychology 74 (1): 39–45.

GABA (Gamma-Amino Butyric acid) is a chemical made in the brain, which acts as a neurotransmitter in the central nervous system, and has been proven to have a natural calming effect, to relieve anxiety, and to improve mood. Early research shows that taking GABA reduces stress, tension, anxiety, confusion, and depression in people under pressure.




*References:
A. Abdou et al., “Relaxation and Immunity Enhancement Effects of Gamma- Aminobutyric Acid (GABA) Administration in Humans," BioFactors 26 (2006): 201–208.
Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (October 2007). "GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations". Physiol. Rev. 87 (4): 1215–1284.

Chamomile (4:1) contains a vast array of compounds including flavonoids and coumarins which are considered smooth muscle relaxants. Chamomile has been used to to treat stress and insomnia, with studies demonstrating anxiolytic (anti-anxiety) and neuroendocrine effects.




*References:
Sarris, J; Panossian, A; Schweitzer, I; Stough, C; Scholey, A (December 2011). "Herbal medicine for depression, anxiety, and insomnia: a review of psychopharmacology and clinical evidence". European neuropsychopharmacology 21 (12): 841–860.
Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J (2009-08-29). "A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder.". Journal of Clinical Pharmacology 29 (4): 378–82.
Singh, O; Khanam, Z; Misra, N; Srivastava, MK (January 2011). "Chamomile (Matricaria chamomilla L.): An overview.". Pharmacognosy reviews 5 (9): 82–95.
Srivastava, JK; Shankar, E; Gupta, S (November 2010). "Chamomile: A herbal medicine of the past with bright future". Molecular medicine reports 3 (6): 895–901.
Gardiner, P (2007). "Complementary, Holistic, and Integrative Medicine: Chamomile". Pediatric Review 28 (4): 16–18.

Ashwagandha (Withania somnifera) is a plant used in Ayurvedic medicine as an “adaptogen" herb for the treatment of stress, fatigue, lack of energy, and difficulty sleeping. Scientific studies support ashwagandha's ability not only to relieve stress, but also to protect brain cells against the deleterious effects of our modern lifestyles. Reported benefits include an increase in energy, reduction in fatigue, enhanced sleep, and an elevated sense of well-being.



*References:
Mirjalili, M. H.; Moyano, E.; Bonfill, M.; Cusido, R. M.; Palazón, J. (2009). "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine". Molecules 14 (7): 2373–2393.
Pandit, S.; Chang, K.-W.; Jeon, J.-G. (February 2013). "Effects of Withania somnifera on the growth and virulence properties of Streptococcus mutans and Streptococcus sobrinus at sub-MIC levels". Anaerobe 19: 1–8.
Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec;7(6):463-9.

DMAE Bitartrate is present in small amounts in our brains and can enhance mental activities, elevate mood, improve memory and learning and increase physical energy. DMAE has been proven to increase the production of brain chemicals essential for sleep regulation, memory, and concentration, as well as, have positive influence on mood. It is a precursor for choline, which is present inside cells, that is converted to phosphatidylcholine and is used in the building and repair of cell membranes, particularly within the brain, acting as a “neurotransmitter" that helps nerve cells communicate. Some suggest that the effects of DMAE are similar to caffeine but more gradual and continuous. It is used for treating a variety of conditions including attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism as well as boosting thinking skills and intelligence; and increasing physical energy, oxygen efficiency, athletic performance, and muscle reflexes.




*References:
Lukoshko SO, Koval'chuk TO, Rybal'chenko VK. The effect of dimethylethanolamine on the summation capacity of the central nervous system and on the work capacity of animals in a chronic experiment. Fiziol Zh 1997;43(1-2):19-22.
Pfeiffer, C. C.; Jenney, E. H.; Gallagher, W; Smith, R. P.; Bevan Jr, W; Killam, K. F.; Killam, E. K.; Blackmore, W (1957). "Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine". Science (New York, N.Y.) 126 (3274): 610–1.

Information on Jet Lag

With more and more people travelling long distances today, a remedy for jet lag has never been more necessary. The global tourism market has grown to huge proportions, business and social travel has been redefined with vast technological advancement in which the ease of booking, traveling and experiencing a journey is beyond simple. Travel spending, hotels, booking sites and destination marketing organizations are adapting to this incredible leap towards a world that is so much more accessible than ever before. Jet lag can be debilitating, with symptoms that can ruin vacations, sabotage business trips or simply wreak havoc on our general health.

There are several things that can be done to combat this condition, with a better understanding of the causes and how to address the symptoms, we can combat jet lag and ensure a superior travel experience.

What is Jet Lag?

Circadian rhythms refer to our body's natural 24-hour sleep/wake cycle, where physical, mental and behavioral changes occur dependent upon & responding to - light and dark stimuli. Jet lag, also referred to as desynchronosis or circadian dysrythmia, is a physiological condition that stems from changes in the body's circadian rhythms from fast long distance travel on high-speed aircraft. Years ago, jet lag was not an issue, only with the evolvement of the passenger jet aircraft, and the ability to travel further and faster, did jet lag become a recognized condition.

Jet lag is a chronobiological condition, that occurs when traveling across a number of time zones. It renders the body's balance (circadian rhythm) out of synchronization. It experiences light/dark in contrast to the rhythms it is used to, upsetting the body's natural balance, so the rhythms that affect eating, sleeping, hormonal regulations, etc. become confused so they no longer correspond to the environment. In addition, they are unable to immediately rectify this quickly and as such the body experiences the symptoms we refer to as jet lag.

Anyone can suffer from jet lag. The direction of travel, distance and each individual will experience jet lag differently.

Jet Lag Symptoms

Symptoms vary from person to person based on the amount of time zone difference, time of day and each individual's health. The most commonly experienced symptoms are sleep disturbances, extreme tiredness, cognitive effects including lowered concentration, headaches and irritability. Additionally, changes in appetite and digestive issues can also occur.

In general, it is suggested that a change of three time zones or more will increase the chances of jet lag occurring, albeit some individuals can be affected by crossing only one time zone. It is thought that a recovery rate of one day per time zone crossed is sufficient for over coming jet lag. If only one time zone has been crossed, some feel that after a day and a good night's sleep, the body should be re-balanced.

There has been a lot of research directed towards athletes and travel, and how jet lag can affect their performance. Physical and mental characteristics can be drastically affected, so a specific measurement scale was devised, called the Liverpool Jet Lag Questionnaire, to ascertain symptoms of jet lag and assess the impact upon their performance in competitions. This provides useful insight into a condition that can affect so many.

Being aware of how jet lag occurs and the effective ways in which we can manage symptoms will help us reduce jet lag and enhance our travel experience like never before.

What are the Causes and Characteristics of Jet Lag?

Many travelers can experience general travel fatigue, which can include symptoms of general tiredness, headache and disorientation. The impact of these symptoms soon disappear once our bodies are re-hydrated effectively and have had a good night's sleep.

However, when we cross multiple time zones, it is not simply travel fatigue but jet lag that we experience. Travelling west-east and east-west (trans-meridian) is more likely to cause jet lag, travelling north-south generally does not present symptoms of jet lag as time zones are not crossed. Generally, travelling east to west travel presents less jet lag symptoms than west to east. This is fundamentally due to the fact that our body clock has to be moved forward, which is more difficult than delaying it. The further we travel, the worse symptoms may present.

It is thought that travelling west results in fewer problems and exposure to light during the day and avoiding it during the night is sufficient to overcome jet lag.

How to Prevent Jet Lag?

Light is one of the strongest regulators for re-aligning sleep-wake schedule, so careful exposure/avoidance of bright lights can speed up adjustment. There is also evidence that melatonin may help reduce jet lag, however, there remains issues regarding the appropriate timing of melatonin use with certain studies actually demonstrating that it has no benefit at all. Its effectiveness is questionable and for certain groups, such as athletes, may even be illegal.

There are many basic steps that you should take to reduce the symptoms of jet lag, even starting days prior before you even fly. Some airlines actually provide jet lag calculators and programs detailing the most effective steps to take to reduce symptoms.

Altering sleep patterns prior to departure, diet and exercise, sleep/stimulating substances, remaining re-hydrated during the flight and sleeping on the plane can all assist in regulating your body clock to avoid the symptoms of jet lag.

References:

1 - The Lancet

2 - British Journal of Sports Medicine

3 - Journal Of Sleep

Jet Relief™ - Frequently Asked Questions:

What makes Jet Relief™ more effective than other jet lag remedies?
Most jet lag formulas combine a few key components with additional inactive ingredients, which can dilute the effectiveness of the product. This creates a cheaper solution and a less effective product. Others use inferior forms of critical ingredients, which just don't work as well. Some products neglect the research and include ingredients that are not even related to relieving jet lag at all.

Only Jet Relief™ uses a 100% natural formula that combines high quality ingredients in their purest forms. This has enabled us to create an effective, dual-action formula that not only relieves the mental and physical stress of travelling and the journey itself, but also helps balance the body's natural sleep/wake cycle (circadian rhythms) in order to get a good night's sleep and wake up feeling rested and back to normal. By combining these approaches, Jet Relief™ has been able to create a superior jet lag remedy that works faster and is more effective than any other product on the market.

Can Jet Relief™ be used to prevent symptoms from occurring?
Yes, we recommend that Jet Relief™ be taken as follows: 2 capsules taken 30 minutes prior to your flight, and two upon arrival (capsules should be taken at least 4 hours apart). One capsule may be taken daily thereafter until the effects of jet lag have completely dissipated. Since Jet Relief™ is made of all natural ingredients, it is safe for long term use.

How long should I use Jet Relief™ ?
One capsule may be taken daily thereafter the initial dose, until the effects of jet lag have completely dissipated.

What makes up the ingredients of Jet Relief™ ?
The ingredients in Jet Relief™ can be found on our How It Works page. You can go there to read more about each of the quality natural herbal ingredients.

Why is Jet Relief™ not available in stores?
We have chosen to make Jet Relief™ available exclusively online, so that we are able to reach more people and maintain control of distribution and customer service. We want to be hands on with our customers if there's a problem; we lose that personal touch when the product is sold in stores.

Can I see the label of Jet Relief™
Of course! Please click here to see our label.

Can I use Jet Relief™ with my prescription medications?
Jet Relief™ has been formulated using only the purest natural ingredients. For the most part, there is no interference with most medications. But if you have any concerns or are pregnant or nursing, we always recommend you consult with your doctor.

If it does not work for me and I want to return it, what do I do?
Not a problem - there is a 60 day money back guarantee. We ask that you call customer service to get your return authorization number. If you do decide to return the bottles, you must return all of the bottles, so do not throw any of them away. Please do not ship products to us after the 60 day period has expired. If you send only a portion of the bottles back, you will receive a partial refund.

Questions about Shipping Jet Relief™:

How soon will my order arrive?
If you choose regular shipping, Jet Relief™ is shipped by US Postal Service First Class Mail. If you place your order before 10:00am EST, it will be shipped out on the day it is ordered. If you place your order after 10:00am EST, it will be sent out the next morning. Your order should arrive within 3 to 5 business days within the USA. All orders received after 10:00am on Friday or on the weekend will be shipped out promptly Monday morning.

We also offer FedEx 2 day delivery, as well as next day shipping. FedEx shipments will be sent out the same day, as long as the order is received by 10:00am EST. You can learn more about shipping options on the checkout page.

What kind of package will it arrive in?
We always ship discreetly to protect the privacy of our customers. Jet Relief™ is shipped in plain packaging with no external information that identifies the product purchased.

How secure is it to order Jet Relief™ online?
Very secure. We use the strongest data encryption Secure Sockets Layer (SSL) technology available. SSL technology is the industry standard for encryption, and ensures a secure transaction environment for commerce on the internet.

Do you ship to Canada?
Yes, we have many customers in Canada; it just takes longer to get there, about 1 to 2 weeks for regular mail. If you order it using the FedEx amount, it will take 4 to 6 days.

Do you ship internationally?
Yes, we can ship to any country. You can learn more about shipping options on the checkout page.